@Gwen-Dragon
Version 2.3.1440.48 (Stable channel) (64-bit)
Revision 38c6381358a1ec7a9fc161a038fb9d7407334aa4-refs/branch-heads/3626@{#858}
OS Windows 10
It's happened with every extension I've tested that opens options as its own local page under chrome-extension://. That is, any extension which has the manifest option "options_ui"->"open_in_tab" set to true. If the extension instead opens options as a popup on the extension page, right-clicking and selecting inspect will successfully open dev tools without issue. Here's a list of extensions I tested:
name: uMatrix
version: 1.3.16
ID: ogfcmafjalglgifnmanfmnieipoejdcf
name: Google Translate
version: 2.0.7
ID: aapbdbdomjkkjkaonfhkkikfgjllcleb
name: uBlock Origin
version: 1.18.4
ID: cjpalhdlnbpafiamejdnhcphjbkeiagm
name: Linkclump
version: 2.8.5
ID: lfpjkncokllnfokkgpkobnkbkmelfefj